Standard selective β
-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2
receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo
. Also available as part of the β-Adrenoceptor Agonist Tocriset™
and Mixed Adrenergic Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline.
Akimoto et al.
J.Smooth Muscle Res., 2002;38:87
Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment.
Lotti et al.
β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf.
Schmitt and Stork
The citations listed below are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:
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