Catalog Number: 1747
Alternate Names: Isoprenaline
Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride
Biological Activity
Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline.
    Akimoto et al.
    J.Smooth Muscle Res., 2002;38:87
  2. Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment.
    Lotti et al.
    J.Auton.Pharmacol., 1982;2:169
  3. β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf.
    Schmitt and Stork
    J.Biol.Chem., 2000;275:25342

The citations listed below are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

Showing Results 1 - 10 of 14

  1. Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.
    Authors: Lang Et al.
    Cereb Cortex
  2. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Circ Arrhythm Electrophysiol
  3. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
    Authors: Sun Et al.
    Nat Commun
  4. Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors.
    Authors: Hansen and Manahan-Vaughan
    Eur J Neurosci
  5. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    J Mol Cell Cardiol
  7. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
  8. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Biochem Biophys Res Commun
  9. Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.
    Authors: Santulli Et al.
    J Cell Biol
  10. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One
  11. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
  12. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Biol Chem
  13. Bitter peptides activate hTAS2Rs, the human bitter receptors.
    Authors: Maehashi Et al.
    PLoS One
  14. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Sci Rep
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