Isoproterenol hydrochloride

  ( 21 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1747
Alternate Names:Isoprenaline
Chemical Name:4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride
Product Details
Citations (21)
Reviews
Biological Activity
Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
    247.72
  • Formula:
    C11H17NO3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >97
  • Storage:
    Store at RT
  • CAS No:
    51-30-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

21 Citations: Showing 1 - 10
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  1. Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.
    Authors: Lang Et al.
    Cereb Cortex  2015;8:409
  2. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Circ Arrhythm Electrophysiol  2015;6:8480
  3. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
    Authors: Sun Et al.
    Nat Commun  2015;5:15950
  4. Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors.
    Authors: Hansen and Manahan-Vaughan
    Eur J Neurosci  2015;25:1889
  5. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    J Mol Cell Cardiol  2015;10:e0132884
  7. Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.
    Authors: Williams Et al.
    Neuropharmacology  2014;86:116
  8. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    Diabetes  2014;66:83
  9. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Biochem Biophys Res Commun  2014;289:14600
  10. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.
    Authors: Zhang Et al.
    PLoS One  2013;8:e66122
  11. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  12. Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
    Authors: Zaytseva Et al.
    Sens Actuators B Chem  2013;188
  13. Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.
    Authors: Santulli Et al.
    J Cell Biol  2012;61:692
  14. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  15. β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
    Authors: Nobis Et al.
    Biol Psychiatry  2011;69:1083
  16. Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.
    Authors: Chigaev Et al.
    J Biol Chem  2011;286:20375
  17. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  18. Reversibly sealed multilayer microfluidic device for integrated cell perfusion and on-line chemical analysis of cultured adipocyte secretions.
    Authors: Clark Et al.
    Anal Bioanal Chem  2010;397:2939
  19. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Biol Chem  2010;31:1646
  20. Bitter peptides activate hTAS2Rs, the human bitter receptors.
    Authors: Maehashi Et al.
    PLoS One  2008;365:851
  21. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Sci Rep  2004;24:7745
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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