Catalog Number: 1747
Alternate Names: Isoprenaline
Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride
Biological Activity
Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
    247.72
  • Formula:
    C11H17NO3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    51-30-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline.
    Akimoto et al.
    J.Smooth Muscle Res., 2002;38:87
  2. Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment.
    Lotti et al.
    J.Auton.Pharmacol., 1982;2:169
  3. β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf.
    Schmitt and Stork
    J.Biol.Chem., 2000;275:25342
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

14 Citations: Showing 1 - 10
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  1. Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.
    Authors: Lang Et al.
    Cereb Cortex 2015;8:409
  2. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Circ Arrhythm Electrophysiol 2015;6:8480
  3. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
    Authors: Sun Et al.
    Nat Commun 2015;5:15950
  4. Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors.
    Authors: Hansen and Manahan-Vaughan
    Eur J Neurosci 2015;25:1889
  5. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    J Mol Cell Cardiol 2015;10:e0132884
  7. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    Diabetes 2014;66:83
  8. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Biochem Biophys Res Commun 2014;289:14600
  9. Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.
    Authors: Santulli Et al.
    J Cell Biol 2012;61:692
  10. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One 2011;6:e27474
  11. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842
  12. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Biol Chem 2010;31:1646
  13. Bitter peptides activate hTAS2Rs, the human bitter receptors.
    Authors: Maehashi Et al.
    PLoS One 2008;365:851
  14. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Sci Rep 2004;24:7745
Expand to show all 14 Citations

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