Chemical Name: N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
Biological ActivityCeapin A7 is a selective inhibitor of ATF6α (IC50=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.
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