Catalog Number: 3786
Alternate Names: SC 58635, Celebrex
Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Biological Activity
Selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (Cat. No. 2895). Displays chemopreventive activity in in vivo tumor models.
Technical Data
  • M.Wt:
    381.37
  • Formula:
    C17H14F3N3O2S
  • Solubility:
    Soluble to 25 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    169590-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
    Penning et al.
    J.Med.Chem., 1997;40:1347
  2. Cox-2-selective Inhibitors: the new super aspirins.
    DeWitt
    Mol.Pharmacol., 1999;55:625
  3. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.
    Harris et al.
    Cancer Res., 2000;60:2101

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