Celecoxib

Key Product Details

Product Description

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀ values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.

Product Specifications for Celecoxib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Celecoxib

The following data is based on the product molecular weight 381.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.24 mL	26.22 mL	52.44 mL
2.5 mM	1.05 mL	5.24 mL	10.49 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
25 mM	0.10 mL	0.52 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• DeWitt Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 1999 PMID: 10101019
• Harris Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 2000 PMID: 10786667
• Penning Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 1997 PMID: 9135032

Product Documents for Celecoxib