Selective cyclooxygenase-2 (COX-2) inhibitor (IC50
values are 15 and 0.04 μ
M for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo
than SC 58121
(Cat. No. 2895). Displays chemopreventive activity in in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Penning et al.
Cox-2-selective Inhibitors: the new super aspirins.
Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.
Harris et al.
Cancer Res., 2000;60:2101