Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Biological ActivitySelective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (Cat. No. 2895). Displays chemopreventive activity in in vivo tumor models.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Penning et al.
Cox-2-selective Inhibitors: the new super aspirins.
Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.
Harris et al.
Cancer Res., 2000;60:2101
Citations for Celecoxib
The citations listed below are publications that use Tocris products. Selected citations for Celecoxib include:
2 Citations: Showing 1 - 2
CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.
Authors: Bowler Et al.
JACC Basic Transl Sci 2019;4:135
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Authors: Oguh-Olayinka Et al.
Pathol Oncol Res 2019;
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Celecoxib
There are currently no reviews for this product. Be the first to review Celecoxib and earn rewards!
Have you used Celecoxib?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image