Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
Biological ActivityHigh affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong et al.
Citation for Centrinone B
The citations listed below are publications that use Tocris products. Selected citations for Centrinone B include:
1 Citation: Showing 1 - 1
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Authors: Chen Et al.
Nat Commun 2017;8:247
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