Centrinone B

Catalog # Availability Size / Price Qty
5690/10
Cat.No. 5690 - Centrinone B | C27H27F2N7O5S2 | CAS No. 1798871-31-4
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Description: High affinity and selective PLK4 inhibitor
Alternative Names: LCR 323

Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

High affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Technical Data

M.Wt:
631.67
Formula:
C27H27F2N7O5S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1798871-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Background References

  1. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
    Wong et al.
    Science, 2015;348:1155

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Citation for Centrinone B

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