Biological Activity High affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
Soluble to 50 mM in DMSO
Store at -20°C
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For batch specific data refer to the Certificate of Analysis.
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