Centrinone B

Tocris Bioscience | Catalog # 5690

High affinity and selective PLK4 inhibitor
Tocris Bioscience

Key Product Details

Description

High affinity and selective PLK4 inhibitor

Alternative Names

LCR 323
View all Polo-like Kinase Inhibitors »

Product Description

Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Product Specifications for Centrinone B

Molecular Weight

631.67

Formula

C27H27F2N7O5S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

CAS Number

1798871-31-4

PubChem ID

118704753

InChI Key

UPZNTUYHCRQOIQ-UHFFFAOYSA-N

SMILES

FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.58 50

Preparing Stock Solutions for Centrinone B

The following data is based on the product molecular weight 631.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.17 mL 15.83 mL 31.66 mL
2.5 mM 0.63 mL 3.17 mL 6.33 mL
5 mM 0.32 mL 1.58 mL 3.17 mL
25 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 27 publications citing the usage of this product.

Product Documents for Centrinone B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Centrinone B

For research use only

Related Research Areas

Intracellular Kinases

Customer Reviews for Centrinone B (1)

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  • T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: T cell line
    Verified Customer | Posted 03/26/2020
    100nM
    Centrinone B 5690

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