Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
Biological ActivityHigh affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong et al.
Citation for Centrinone B
The citations listed below are publications that use Tocris products. Selected citations for Centrinone B include:
1 Citation: Showing 1 - 1
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Authors: Chen Et al.
Nat Commun 2017;8:247
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