Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50
values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro
. Also inhibits Pkc1. Orally bioavailable.
Soluble to 10 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening.
Sussman et al.
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
Konicek et al.
Cancer Res., 2011;71:1849
Targeting Mnks for cancer therapy.
Hou et al.