Cercosporamide

Key Product Details

Product Description

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC₅₀ values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.

Product Specifications for Cercosporamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cercosporamide

The following data is based on the product molecular weight 331.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.19 mL	150.93 mL	301.86 mL
0.5 mM	6.04 mL	30.19 mL	60.37 mL
1 mM	3.02 mL	15.09 mL	30.19 mL
5 mM	0.60 mL	3.02 mL	6.04 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Hou Targeting Mnks for cancer therapy. Oncotarget 2012 PMID: 22392765
• Sussman Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 2004 PMID: 15302826
• Konicek Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 2011 PMID: 21233335

Product Documents for Cercosporamide