Cerestat

Key Product Details

Product Description

Cerestat is a potent and noncompetitive NMDA receptor antagonist (IC₅₀ = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.

Product Specifications for Cerestat

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cerestat

The following data is based on the product molecular weight 339.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.71 mL	29.42 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schäbitz The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 2000 PMID: 10884477
• Reddy Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 1994 PMID: 8295213

Product Documents for Cerestat