Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Biological ActivityCerestat is a potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.
Reddy et al.
The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats.
Schäbitz et al.
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