Ceritinib

Catalog # Availability Size / Price Qty
6905/10
6905/50
Ceritinib | CAS No. 1032900-25-6 | ALK Inhibitors
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Description: Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
Alternative Names: LDK378

Chemical Name: 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine

Purity: ≥98%

Product Details
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Biological Activity

Highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.

Technical Data

M.Wt:
558.14
Formula:
C28H36ClN5O3S
Solubility:
Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1032900-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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