Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Biological ActivityCetirizine dihydrochloride is a histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria.
Campoli-Richards et al.
Cetirizine: actions on neurotransmitter receptors.
Snowman and Snyder
Effects of cetirizine on human eosinophil and neutrophil activation in vitro.
Walsh et al.
Int.Arch.Allergy Appl.Immunol., 1991;95:158
Citations for Cetirizine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:
4 Citations: Showing 1 - 4
Mast Cells in the Developing Brain Determine Adult Sexual Behavior.
Authors: Lenz Et al.
J Neurosci 2018;38:8044
PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.
Authors: Ito Et al.
PLoS One 2015;11:547
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
Authors: Kemp Et al.
J Biol Chem 2014;289:26574
Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
Authors: Kim Et al.
Korean J Physiol Pharmacol 2013;17:149
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