Catalog Number: 2577
Alternate Names: P 071
Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Biological Activity
Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria.
    Campoli-Richards et al.
    Drugs, 1990;40:762
  2. Cetirizine: actions on neurotransmitter receptors.
    Snowman and Snyder
    J.Allergy.Clin.Immunol., 1990;86:1025
  3. Effects of cetirizine on human eosinophil and neutrophil activation in vitro.
    Walsh et al.
    Int.Arch.Allergy Appl.Immunol., 1991;95:158

The citations listed below are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:

Showing Results 1 - 3 of 3

  1. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.
    Authors: Ito Et al.
    PLoS One
  2. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
    Authors: Kemp Et al.
    J Biol Chem
  3. Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
    Authors: Kim Et al.
    Korean J Physiol Pharmacol
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