Cetrorelix acetate

Name: Cetrorelix acetate
Brand: Tocris Bioscience
SKU: 8821
Price: 169 USD
Availability: InStock

Tocris Bioscience | Catalog # 8821

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Product Documents

Potent GnRH receptor antagonist

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent GnRH receptor antagonist

View all GnRH Antagonist »

Product Description

Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (K_D = 0.202 nM, IC₅₀ = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

Product Specifications for Cetrorelix acetate

Molecular Weight

1431.06

Formula

C₇₀H₉₂ClN₁₇O₁₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

145672-81-7

PubChem ID

25074887

InChI Key

SBNPWPIBESPSIF-MHWMIDJBSA-N

SMILES

CC(C[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(N)=O)C)=O)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)CO)=O)CC6=CC=C(C=C6)O)=O)CCCNC(N)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 0.02 M acetic acid

Calculators

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Background References

References are publications that support the biological activity of the product.

Gründker and Emons Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 2003 PMID: 14594454
Telegdy Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 2009 PMID: 19375162
Beckers Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 1997 PMID: 9300077

Product Documents for Cetrorelix acetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Cetrorelix acetate

For research use only

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