Cevimeline hydrochloride
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Biological Activity
Cevimeline hydrochloride is a selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954.
Wanibuchi et al.
Eur.J.Pharmacol., 1990;187:479 -
(+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Fisher et al.
J.Pharmacol.Exp.Ther., 1991;257:392 -
L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
Hargreaves et al.
Br.J.Pharmacol., 1992;107:494
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