Catalog Number: 3689
Alternate Names: AF 102B, SNI 2011
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Biological Activity
Selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.
Technical Data
  • M.Wt:
    235.77
  • Formula:
    C10H17NOS.HCl
  • Solubility:
    Soluble to 75 mM in water and to 50 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    107220-28-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
    Fisher et al.
    J.Pharmacol.Exp.Ther., 1991;257:392
  2. Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954.
    Wanibuchi et al.
    Eur.J.Pharmacol., 1990;187:479
  3. L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
    Hargreaves et al.
    Br.J.Pharmacol., 1992;107:494

Have you used Cevimeline hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information