Catalog Number: 3219
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Biological Activity
Selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.
Technical Data
  • M.Wt:
    187.6
  • Formula:
    C5H14NO2P.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    123691-29-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain.
    Ong et al.
    Eur.J.Pharmacol., 2001;415:191
  2. Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
    Froestl et al.
    J.Med.Chem., 1995;38:3313
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation.
    Authors: Chen Et al.
    J Neurosci 2015;4

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