CGP 37157

Catalog # Availability Size / Price Qty
CGP 37157 | CAS No. 75450-34-9 | Na+/Ca2+ Exchanger Inhibitors
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Description: Antagonist of mitochondrial Na+/Ca2+ exchange

Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Purity: ≥99%

Product Details
Citations (13)

Biological Activity

CGP 37157 is a selective antagonist of the mitochondrial Na+/Ca2+ exchanger (NCX; IC50 = 0.4 μM).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CGP 37157

The citations listed below are publications that use Tocris products. Selected citations for CGP 37157 include:

13 Citations: Showing 1 - 10

  1. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
    Authors: Panja Et al.
    Neuropathol Appl Neurobiol  2019;45:141
  2. Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.
    Authors: Bastioli Et al.
    Cell Death Dis  2019;10:80
  3. Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
    Authors: Yang Et al.
    J Biol Chem  2015;4
  4. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
    World J Gastroenterol  2015;290:28214
  5. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    Elife  2015;16:5555
  6. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release.
    Authors: Blomeyer Et al.
    J Bioenerg Biomembr  2013;45:189
  7. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
    Authors: Pandit Et al.
    Am J Physiol Renal Physiol  2012;302:F1325
  8. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One  2011;6:e25395
  9. Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
    Authors: Zhdanov Et al.
    Cell Mol Life Sci  2011;68:903
  10. Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.
    Authors: Lee Et al.
    J Neurosci  2007;27:13603


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