Catalog Number: 1114
Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Biological Activity
Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons.
    Baron and Thayer
    Eur.J.Pharmacol., 1997;340:295
  2. Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157.
    Cox et al.
    J.Cardiovasc.Pharmacol., 1993;21:595
  3. Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange.
    Cox and Matlib
    TiPS, 1993;14:408
  4. Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.
    White and Reynolds
    J.Physiol., 1997;498:31
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