CGP 37157

  ( 9 citations )    
Product Datasheet
Catalog Number:1114
Chemical Name:7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Product Details
Citations (9)
Biological Activity
Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for CGP 37157 include:

9 Citations: Showing 1 - 9
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  1. Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
    Authors: Yang Et al.
    J Biol Chem  2015;4
  2. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
    World J Gastroenterol  2015;290:28214
  3. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    Elife  2015;16:5555
  4. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release.
    Authors: Blomeyer Et al.
    J Bioenerg Biomembr  2013;45:189
  5. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
    Authors: Pandit Et al.
    Am J Physiol Renal Physiol  2012;302:F1325
  6. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One  2011;6:e25395
  7. Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
    Authors: Zhdanov Et al.
    Cell Mol Life Sci  2011;68:903
  8. Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity.
    Authors: Kim Et al.
    J Biol Chem  2006;12:796
  9. Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration.
    Authors: Schild Et al.
    Am J Physiol Heart Circ Physiol  2003;278:25454


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