CGP 37157

Key Product Details

Product Description

CGP 37157 is a selective antagonist of the mitochondrial Na⁺/Ca²⁺ exchanger (NCX; IC₅₀ = 0.4 μM).

Product Specifications for CGP 37157

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGP 37157

The following data is based on the product molecular weight 324.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.84 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 129 publications citing the usage of this product.

• White and Reynolds Mitochondria accumulate Ca²⁺ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 1997 PMID: 9023766
• Cox Selectivity of inhibition of Na⁺-Ca²⁺ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 1993 PMID: 7681905
• Cox and Matlib Modulation of intramitochondrial free Ca²⁺ concentration by antagonists of Na⁺-Ca²⁺ exchange. TiPS 1993 PMID: 8296399
• Baron and Thayer CGP37157 modulates mitochondrial Ca²⁺ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 1997 PMID: 9537826

Product Documents for CGP 37157