Catalog Number: 1469
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Biological Activity
Potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.
Technical Data
  • M.Wt:
    209.14
  • Formula:
    C6H12NO5P
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    127910-31-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity.
    Fagg et al.
    Br.J.Pharmacol., 1990;99:791
  2. Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
    Pozza et al.
    Eur.J.Pharmacol., 1990;182:91
  3. Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
    Loscher and Honack
    J.Pharmacol.Exp.Ther., 1991;256:432
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 37849 include:

1 Citations: Showing 1 - 1

  1. Prenatal stress enhances excitatory synaptic transmission and impairs long-term potentiation in the frontal cortex of adult offspring rats.
    Authors: Sowa Et al.
    PLoS One 2015;10:e0119407

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