Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Biological ActivityCGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CGP 37849 and CGP 39551: novel and potent competitive N-MthD.-asparate receptor antagonists with oral activity.
Fagg et al.
Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
Pozza et al.
Anticonvulsant and behavioural effects of two novel competitive N-MthD.-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamaz.
Loscher and Honack
Citations for CGP 37849
The citations listed below are publications that use Tocris products. Selected citations for CGP 37849 include:
3 Citations: Showing 1 - 3
Activity-dependent differences in function between proximal and distal Schaffer collaterals.
Authors: Owen and Grover
J Neurophysiol 2015;113:3646
Prenatal stress enhances excitatory synaptic transmission and impairs long-term potentiation in the frontal cortex of adult offspring rats.
Authors: Sowa Et al.
PLoS One 2015;10:e0119407
Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
Authors: Kim Et al.
J Neurophysiol 2012;108:1965
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