Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid
Biological ActivityCGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study.
Curtis and Lacey
Exp.Brain Res., 1998;121:319
GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
Staubli et al.
Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381.
Lingenhoehl and Olpe
Potent, orally active GABAB receptor antagonists.
Froestl et al.
Citations for CGP 46381
The citations listed below are publications that use Tocris products. Selected citations for CGP 46381 include:
5 Citations: Showing 1 - 5
17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
J Neurosci 2016;36:2677
GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs.
Authors: Cheng Et al.
Front Cell Neurosci 2015;2015:207312
Intrinsic modulators of auditory thalamocortical transmission.
Authors: Lee and Sherman
Hear Res 2012;287:43
Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Authors: Pacey Et al.
Biomed Res Int 2011;338:897
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
Authors: Costa Et al.
J Neurosci 2008;28:8040
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