CGP 46381

Key Product Details

Product Description

CGP 46381 is a brain penetrant, selective GABA_B receptor antagonist (IC₅₀ = 4.9 μM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications for CGP 46381

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGP 46381

The following data is based on the product molecular weight 219.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.56 mL	22.80 mL	45.61 mL
5 mM	0.91 mL	4.56 mL	9.12 mL
10 mM	0.46 mL	2.28 mL	4.56 mL
50 mM	0.09 mL	0.46 mL	0.91 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

• Froestl Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm.
• Staubli GABA_B receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 1999 PMID: 10341258
• Lingenhoehl and Olpe Blockade of the late inhibitory postsynaptic potential in vivo by the GABA_B antagonist CGP 46381. Pharmacol.Comm.
• Curtis and Lacey Prolonged GABA_B receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 1998 PMID: 9746138

Product Documents for CGP 46381