CGP 46381

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CGP 46381 | CAS No. 123691-14-5 | GABA-B Receptor Antagonists
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Description: Selective GABAB antagonist; brain penetrant

Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid

Product Details
Citations (5)
Supplemental Products

Biological Activity

CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novartis Pharma AG

Background References

  1. Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study.
    Curtis and Lacey
    Exp.Brain Res., 1998;121:319
  2. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
    Staubli et al.
    J.Neurosci., 1999;19:4609
  3. Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381.
    Lingenhoehl and Olpe
    Pharmacol.Comm., 1993;3:49
  4. Potent, orally active GABAB receptor antagonists.
    Froestl et al.
    Pharmacol.Rev.Comm., 1996;8:127

Product Datasheets

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Citations for CGP 46381

The citations listed below are publications that use Tocris products. Selected citations for CGP 46381 include:

5 Citations: Showing 1 - 5


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