Catalog Number: 1247
Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid
Biological Activity
Brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study.
    Curtis and Lacey
    Exp.Brain Res., 1998;121:319
  2. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
    Staubli et al.
    J.Neurosci., 1999;19:4609
  3. Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381.
    Lingenhoehl and Olpe
    Pharmacol.Comm., 1993;3:49

The citations listed below are publications that use Tocris products. Selected citations for CGP 46381 include:

Showing Results 1 - 4 of 4

  1. GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs.
    Authors: Cheng Et al.
    Front Cell Neurosci
  2. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res
  3. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Biomed Res Int
  4. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci
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