CGP 53353

  ( 3 citations )    
Product Datasheet
Catalog Number:2442
Chemical Name:5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Product Details
Citations (3)
Reviews
Biological Activity
Selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.
Technical Data
  • M.Wt:
    365.34
  • Formula:
    C20H13F2N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    145915-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 53353 include:

3 Citations: Showing 1 - 3
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  1. PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils.
    Authors: Liu Et al.
    Mol Biol Cell  2014;25:1446
  2. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.
    Authors: He Et al.
    J Neurosci  2011;18:39
  3. Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth.
    Authors: Ramana Et al.
    Endocrinology  2007;148:4371

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