CGP 53353

Catalog # Availability Size / Price Qty
2442/10
CGP 53353 | CAS No. 145915-60-2 | Protein Kinase C Inhibitors
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Description: Selective inhibitor of PKCβII

Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

Purity: ≥99%

Product Details
Citations (3)
Reviews

Biological Activity

Selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Technical Data

M.Wt:
365.34
Formula:
C20H13F2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
145915-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells.
    Kouroedov et al.
    Circulation, 2004;110:91
  2. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
    Wang et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:7159

Product Datasheets

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Citations for CGP 53353

The citations listed below are publications that use Tocris products. Selected citations for CGP 53353 include:

3 Citations: Showing 1 - 3

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