Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Biological ActivityCGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells.
Kouroedov et al.
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Wang et al.
Citations for CGP 53353
The citations listed below are publications that use Tocris products. Selected citations for CGP 53353 include:
3 Citations: Showing 1 - 3
PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils.
Authors: Liu Et al.
Mol Biol Cell 2014;25:1446
Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.
Authors: He Et al.
J Neurosci 2011;18:39
Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth.
Authors: Ramana Et al.
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