Selective inhibitor of PKCβ
values are 0.41 and 3.8 μ
M for PKCβ
II and PKCβ
I respectively). Also inhibits prionogenic Sup35 fibrillization (IC50
~ 3.4 μ
M) and inhibits de novo
42 assembly in vitro
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Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells.
Kouroedov et al.
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for CGP 53353 include:
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