CGP 57380

Catalog # Availability Size / Price Qty
2731/10
2731/50
2731/1
CGP 57380 | CAS No. 522629-08-9 | Mnk Inhibitors
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Description: Selective inhibitor of Mnk1

Chemical Name: N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine

Purity: ≥98%

Product Details
Citations (7)
Reviews (1)

Biological Activity

CGP 57380 is an inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.

Technical Data

M.Wt:
244.23
Formula:
C11H9FN6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
522629-08-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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(CGP57380, 10 μM)
By Anonymous on 12/11/2019
Application: Species: Human

Cells were treated with MG-132 (15 µM) for 18 hours in the absence or presence of an eIF4E/eIF4G interaction inhibitor (4EGI-1, 50 µM) or an MNK inhibitor (CGP57380, 10 μM).

PMID: 27626179

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