CGP 57380

Tocris Bioscience | Catalog # 2731

Selective inhibitor of Mnk1
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of Mnk1
View all Mnk Inhibitors »

Product Description

CGP 57380 is an inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.

Product Specifications for CGP 57380

Molecular Weight

244.23

Formula

C11H9FN6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine

CAS Number

522629-08-9

PubChem ID

11644425

InChI Key

UQPMANVRZYYQMD-UHFFFAOYSA-N

SMILES

NC1=C2C(NC3=CC=C(F)C=C3)=NNC2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.42 100

Preparing Stock Solutions for CGP 57380

The following data is based on the product molecular weight 244.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.95 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for CGP 57380

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 57380

For research use only

Related Research Areas

Interferons

Customer Reviews for CGP 57380 (1)

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  • (CGP57380, 10 μM)
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: LP-1 cell line
    Verified Customer | Posted 12/11/2019
    Cells were treated with MG-132 (15 µM) for 18 hours in the absence or presence of an eIF4E/eIF4G interaction inhibitor (4EGI-1, 50 µM) or an MNK inhibitor (CGP57380, 10 μM).
    CGP 57380 2731

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