Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50
= 2.2 μ
M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50
= 3 μ
M) and inhibits LPS-induced TNFα
expression in macrophages.
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Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.
Ishida et al.
Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages.
Andersson and Sundler
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.
Knauf et al.
The citations listed below are publications that use Tocris products. Selected citations for CGP 57380 include:
Showing Results 1 - 3 of 3