CGS 35066

Tocris Bioscience | Catalog # 2512

Endothelin-converting enzyme (ECE) inhibitor
Tocris Bioscience

Key Product Details

Description

Endothelin-converting enzyme (ECE) inhibitor
View all Additional Synthetic Protease Inhibitors »

Product Description

CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Product Specifications for CGS 35066

Molecular Weight

349.28

Formula

C16H16NO6P

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid

CAS Number

261619-50-5

PubChem ID

9863167

InChI Key

CRUVAUSVWLATAE-ZDUSSCGKSA-N

SMILES

O=C([C@@H](NCP(O)(O)=O)CC1=CC3=C(C2=CC=CC=C2O3)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 34.92 100

Preparing Stock Solutions for CGS 35066

The following data is based on the product molecular weight 349.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for CGS 35066

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGS 35066

For research use only

Customer Reviews for CGS 35066 (1)

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  • Piglet Unilateral Ureteral Obstruction model to study kidney injury and role of RAAS pathway.
    Name: Vaishali Soni
    Species: Piglet
    Assay Type: In Vivo
    Verified Customer | Posted 01/18/2018
    Compound was dissolved in DMSO to make stock and then formulated using 20% captisol in normal saline. However, we can not disclose the dose used to perform study due to confidentiality of data that not yet published.
    Piglet Unilateral Ureteral Obstruction model to study kidney injury and role of RAAS pathway. Sample used for NGAL measurement (ELISA) is Urine. Bosentan: dual endothelin receptor antagonist CGS 35066: endothelin-converting enzyme (ECE) inhibitor Pyr3:Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3) All compound used intravenously after performing surgery on piglet.
    CGS 35066 2512

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