Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
Biological Activity Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).
Soluble to 100 mM in 1eq. NaOH
Desiccate at RT
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