Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50
values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro
and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).
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Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
De Lombaert et al.
Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
Trapani et al.
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
Kwan et al.