CGS 35066

Catalog # Availability Size / Price Qty
2512/10
CGS 35066 | CAS No. 261619-50-5 | Additional Synthetic Protease Inhibitors
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Description: Endothelin-converting enzyme (ECE) inhibitor

Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Technical Data

M.Wt:
349.28
Formula:
C16H16NO6P
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
261619-50-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
    De Lombaert et al.
    J.Med.Chem., 2000;43:488
  2. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
    Trapani et al.
    J.Cardiovasc.Pharmacol., 2000;36:S40
  3. Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
    Kwan et al.
    Neuropharmacol.Neurotoxicol., 2002;13:197

Product Datasheets

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Piglet Unilateral Ureteral Obstruction model to study kidney injury and role of RAAS pathway.
By Vaishali Soni on 01/18/2018
Species: Other

Piglet Unilateral Ureteral Obstruction model to study kidney injury and role of RAAS pathway.Sample used for NGAL measurement (ELISA) is Urine.Bosentan: dual endothelin receptor antagonistCGS 35066: endothelin-converting enzyme (ECE) inhibitorPyr3:Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3)All compound used intravenously after performing surgery on piglet.


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