Catalog Number: 2512
Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
Biological Activity
Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
    De Lombaert et al.
    J.Med.Chem., 2000;43:488
  2. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
    Trapani et al.
    J.Cardiovasc.Pharmacol., 2000;36:S40
  3. Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
    Kwan et al.
    Neuropharmacol.Neurotoxicol., 2002;13:197
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