Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
Biological ActivityPotent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
De Lombaert et al.
Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
Trapani et al.
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
Kwan et al.
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Piglet Unilateral Ureteral Obstruction model to study kidney injury and role of RAAS pathway.Sample used for NGAL measurement (ELISA) is Urine.Bosentan: dual endothelin receptor antagonistCGS 35066: endothelin-converting enzyme (ECE) inhibitorPyr3:Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3)All compound used intravenously after performing surgery on piglet.