CHDI 00390576

Key Product Details

Product Description

CHDI 00390576 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC₅₀ values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant.

Licensing Information

Sold under license from CHDI Foundation

Product Specifications for CHDI 00390576

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHDI 00390576

The following data is based on the product molecular weight 391.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.78 mL	25.55 mL
5 mM	0.51 mL	2.56 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Luckhurst Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg.Med.Chem.Lett. 2019 PMID: 30463802

Product Documents for CHDI 00390576