CHDI 00484077

Key Product Details

Product Description

CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC₅₀ values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.

Licensing Information

Sold under license from CHDI Foundation

Product Specifications for CHDI 00484077

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHDI 00484077

The following data is based on the product molecular weight 382.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.08 mL	26.15 mL
5 mM	0.52 mL	2.62 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Stott Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 2021 PMID: 33738065

Product Documents for CHDI 00484077