Chetomin

Tocris Bioscience | Catalog # 4705

Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
Tocris Bioscience
Discontinued Product
4705 has been discontinued. View all HIF Inhibitors products.

Key Product Details

Description

Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
View all HIF Inhibitors »

Product Description

Chetomin is a targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.

Product Specifications for Chetomin

Molecular Weight

710.87

Formula

C31H30N6O6S4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

CAS Number

1403-36-7

PubChem ID

90488965

InChI Key

ZRZWBWPDBOVIGQ-KIDIPURZSA-N

SMILES

CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for Chetomin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Chetomin

For research use only

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