Catalog Number: 1001
Alternate Names: 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide
Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide
Biological Activity
An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.
Technical Data
  • M.Wt:
    611.95
  • Formula:
    C14H20Cl4I2N2
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    96750-66-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro.
    El-Bizri and Clarke
    Br.J.Pharmacol., 1994;111:406
  2. Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine.
    El-Bizri and Clarke
    Br.J.Pharmacol., 1994;113:917
  3. The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion.
    Clarke et al.
    Br.J.Pharmacol., 1994;111:397
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:

3 Citations: Showing 1 - 3
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  1. Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy.
    Authors: Sabharwal Et al.
    J Exp Med 2015;100:776
  2. Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy.
    Authors: Sabharwal Et al.
    J Cereb Blood Flow Metab 2014;127:101
  3. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve.
    Authors: Luyer Et al.
    Clin Sci (Lond) 2005;202:1023

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