CHMFL-FLT3-122

   
Product Datasheet
Catalog Number:5800
Chemical Name:1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone
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Biological Activity
Potent and selective FLT3 inhibitor (IC50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G0/G1 phase in vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.
Technical Data
  • M.Wt:
    471.55
  • Formula:
    C26H29N7O2
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    1839150-56-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human Flt-3/Flk-2 (NP_004110) VersaClone cDNA

RDC1174
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Mouse Flt-3/Flk-2 (NP_034359) VersaClone cDNA

RDC1216
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