CHMFL-FLT3-122

Catalog # Availability Size / Price Qty
5800/10
5800/50
Cat.No. 5800 - CHMFL-FLT3-122 | C26H29N7O2 | CAS No. 1839150-56-9
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Description: Potent and selective FLT3 inhibitor

Chemical Name: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone

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Biological Activity

Potent and selective FLT3 inhibitor (IC50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G0/G1 phase in vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.

Technical Data

M.Wt:
471.55
Formula:
C26H29N7O2
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
1839150-56-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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