Aminopeptidase inhibitor (IC50
values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4
hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro
and in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Aminopeptidase inhibition as a targeted treatment strategy in myeloma.
Moore et al.
Mol.Cancer Ther., 2009;8:762
CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Krige et al.
Cancer Res., 2008;68:6669