CHR 6494 trifluoroacetate

Key Product Details

Product Description

CHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC₅₀ = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G₂/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.

Product Specifications for CHR 6494 trifluoroacetate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHR 6494 trifluoroacetate

The following data is based on the product molecular weight 406.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Huertas Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 2012 PMID: 21804608

Product Documents for CHR 6494 trifluoroacetate