CHR 6494 trifluoroacetate
Chemical Name: 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate
Biological ActivityCHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.
Huertas et al.
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