Potent and selective haspin kinase inhibitor (IC50
= 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2
/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo
and attenuates tumor growth of HCT-116 xenografts in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.
Huertas et al.