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CHR 6494 trifluoroacetate

Catalog #: 5326 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5326/10
CHR 6494 trifluoroacetate | CAS No. 1458630-17-5 | Haspin Inhibitors
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Description: Potent and selective haspin inhibitor

Chemical Name: 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate

Purity: ≥98%

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Biological Activity

CHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.

Technical Data

M.Wt:
406.36
Formula:
C16H16N6.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1458630-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.
    Huertas et al.
    Oncogene, 2012;31:1408

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