Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Biological ActivitySelective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.
Krause et al.
J.Lipid Res., 1993;34:279
Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents.
Sliskovic and White
Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.
Drecktrah et al.
Citations for CI 976
The citations listed below are publications that use Tocris products. Selected citations for CI 976 include:
2 Citations: Showing 1 - 2
Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ
Authors: Pagliuso Et al.
Nature Communications 2016;7:12148
Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.
Authors: Schmidt and Brown
J Cell Biol 2009;186:211
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