Catalog Number: 2227
Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Biological Activity
Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).
Technical Data
  • M.Wt:
    393.57
  • Formula:
    C23H39NO4
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    114289-47-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.
    Krause et al.
    J.Lipid Res., 1993;34:279
  2. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents.
    Sliskovic and White
    TiPS., 1991;12:194
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CI 976 include:

2 Citations: Showing 1 - 2
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  1. Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ
    Authors: Pagliuso Et al.
    Nature Communications 2016;7:12148
  2. Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.
    Authors: Schmidt and Brown
    J Cell Biol 2009;186:211

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