CI 976

Catalog # Availability Size / Price Qty
2227/10
2227/50
CI 976 | CAS No. 114289-47-3 | Acyl-CoA:Cholesterol Acyltransferase Inhibitors
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Description: Selective ACAT inhibitor

Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).

Technical Data

M.Wt:
393.57
Formula:
C23H39NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
114289-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.
    Krause et al.
    J.Lipid Res., 1993;34:279
  2. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents.
    Sliskovic and White
    TiPS., 1991;12:194
  3. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.
    Drecktrah et al.
    Mol.Biol.Cell, 2003;14:3549

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Citations for CI 976

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