CIA 1

Key Product Details

Product Description

CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC₅₀ ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.

Product Specifications for CIA 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CIA 1

The following data is based on the product molecular weight 365.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.67 mL	68.33 mL	136.66 mL
1 mM	2.73 mL	13.67 mL	27.33 mL
2 mM	1.37 mL	6.83 mL	13.67 mL
10 mM	0.27 mL	1.37 mL	2.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 2020 PMID: 32494682

Product Documents for CIA 1