Chemical Name: N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Biological ActivityCIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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