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Cilnidipine

2629 1 Review Datasheet / COA / SDS
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2629/10
2629/50
Cilnidipine | CAS No. 132203-70-4 | Cav1.x Channel Blockers
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Description: Dual CaV1.x and CaV2.x blocker
Alternative Names: FRC 8653

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

Purity: ≥99%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Technical Data

M.Wt:
492.52
Formula:
C27H28N2O7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
132203-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine.
    Murai et al.
    Brain Res., 2000;854:6
  2. Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model.
    Takahara et al.
    Biol.Pharm.Bull., 2004;27:1388
  3. The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists.
    Nap et al.
    Fund.Clin.Pharmacol., 2004;18:309

Product Datasheets

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The effect of Cilnidipine was studied on the N-type Ca2+ channel
By Anonymous on 02/12/2019
Application: Species: Human

The effect of Cilnidipine was studied on the N-type Ca2+ channel. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.

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