Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Biological ActivityCilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
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Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine.
Murai et al.
Brain Res., 2000;854:6
Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model.
Takahara et al.
The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists.
Nap et al.
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The effect of Cilnidipine was studied on the N-type Ca2+ channel. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.