Cilnidipine

Tocris Bioscience | Catalog # 2629

Dual CaV1.x and CaV2.x blocker
Tocris Bioscience
Discontinued Product
2629 has been discontinued. View all Cav1.x Channel Blockers products.

Key Product Details

Description

Dual CaV1.x and CaV2.x blocker

Alternative Names

FRC 8653
View all Cav1.x Channel Blockers »

Product Description

Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Product Specifications for Cilnidipine

Molecular Weight

492.52

Formula

C27H28N2O7

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

CAS Number

132203-70-4

PubChem ID

2752

InChI Key

KJEBULYHNRNJTE-UHFFFAOYSA-N

SMILES

COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.25 100
Ethanol 4.92 10

Preparing Stock Solutions for Cilnidipine

The following data is based on the product molecular weight 492.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.30 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.20 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for Cilnidipine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cilnidipine

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Cilnidipine (1)

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  • The effect of Cilnidipine was studied on the N-type Ca2+ channel
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/12/2019
    The effect of Cilnidipine was studied on the N-type Ca2+ channel. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.
    Cilnidipine 2629

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