Catalog Number: 2025
Alternate Names: Ro 24-5913
Chemical Name: 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
Biological Activity
Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ro 24-5913: a potent, specific, orally active LTD4 antagonist.
    Ann.N.Y.Acad.Sci., 1991;629:413
  2. Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4.
    O'Donnell et al.
    J.Pharmacol.Exp.Ther., 1991;259:751
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