Discontinued Product

2025 has been discontinued.
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Cinalukast | CAS No. 128312-51-6 | Leukotriene and Related Receptor Antagonists
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Description: Potent, selective CysLT1 (LTD4) antagonist; orally active
Alternative Names: Ro 24-5913

Chemical Name: 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.

Technical Data

Soluble to 10 mM in ethanol and to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ro 24-5913: a potent, specific, orally active LTD4 antagonist.
    Ann.N.Y.Acad.Sci., 1991;629:413
  2. Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4.
    O'Donnell et al.
    J.Pharmacol.Exp.Ther., 1991;259:751

Product Datasheets

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Citation for Cinalukast

The citations listed below are publications that use Tocris products. Selected citations for Cinalukast include:

1 Citation: Showing 1 - 1

  1. Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
    Authors: Wright Et al.
    Biochem Biophys Res Commun  2019;520:35


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