Cinalukast

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Cinalukast | CAS No. 128312-51-6 | Leukotriene and Related Receptor Antagonists
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Description: Potent, selective CysLT1 (LTD4) antagonist; orally active
Alternative Names: Ro 24-5913

Chemical Name: 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid

Purity: ≥98%

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Biological Activity

Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.

Technical Data

M.Wt:
412.55
Formula:
C23H28N2O3S
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
128312-51-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ro 24-5913: a potent, specific, orally active LTD4 antagonist.
    O'Donnell
    Ann.N.Y.Acad.Sci., 1991;629:413
  2. Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4.
    O'Donnell et al.
    J.Pharmacol.Exp.Ther., 1991;259:751

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