CIQ

Catalog # Availability Size / Price Qty
4105/10
4105/50
Additional NMDA Receptor Compounds Small Molecule
1 Image
Description: Potentiator of NMDA receptors containing GluN2C/GluN2D

Chemical Name: (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Subunit-selective potentiator of NMDA receptors containing the GluN2C (formally NR2C) or GluN2D (formally NR2D) subunit. Increases channel opening efficiency and enhances NMDA receptor responses.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
467.94
Formula:
C26H26ClNO5
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with sonication
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
486427-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
    Mullasseril et al.
    Nat.Commun., 2010;1:1

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Citations for CIQ

The citations listed below are publications that use Tocris products. Selected citations for CIQ include:

2 Citations: Showing 1 - 2

  1. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A.  2017;114(33):8865
  2. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601

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