Catalog Number: 1427
Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Biological Activity
Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Deuterated analog also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol and to 10 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo.
    Auerbach and Hjorth
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;352:597
  3. Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo.
    Mateo et al.
    Neuropharmacology, 2000;39:2036

The citations listed below are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:

9 Citations: Showing 1 - 9
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  1. Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Authors: Phelps Et al.
    Mol Ther 2015;232:2697
  2. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
    Authors: Munari Et al.
    Psychopharmacology (Berl) 2015;18:pyv045
  3. Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation.
    Authors: Jury Et al.
    PLoS One 2015;10:e0117339
  4. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Cardiovasc Res 2012;37:321
  5. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    PLoS One 2012;20:1516
  6. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Int J Neuropsychopharmacol 2010;85:593
  7. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med 2010;16:694
  8. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry.
    Authors: Maciag Et al.
    Neuropsychopharmacology 2006;31:47
  9. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res 2006;1125:171
Tocris Small Molecules
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Citalopram - d4 hydrobromide

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