Citalopram hydrobromide

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1427/10
1427/50

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Citalopram hydrobromide | CAS No. 59729-32-7 | 5-HT Transporter Inhibitors
1 Image
Description: Highly potent and selective 5-HT uptake inhibitor

Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

Purity: ≥99%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Technical Data

M.Wt:
405.31
Formula:
C20H21FN2O.HBr
Solubility:
Soluble to 50 mM in ethanol and to 10 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
59729-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo.
    Auerbach and Hjorth
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;352:597
  3. Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo.
    Mateo et al.
    Neuropharmacology, 2000;39:2036
  4. Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity.
    Hyttel
    Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch, 1982;6:277
  5. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor cital. on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo.
    Auerbach and Hjorth
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;352:597
  6. Inhibition of 5-hydroxytryptamine reuptake by the antidepressant cital. in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo.
    Mateo et al.
    Neuropharmacology, 2000;39:2036

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Citations for Citalopram hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:

14 Citations: Showing 1 - 10

  1. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  2. Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex.
    Authors: Gasull-Camôs Et al.
    Neuropharmacology  2018;139:41
  3. Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Authors: Phelps Et al.
    Mol Ther  2015;232:2697
  4. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
    Authors: Munari Et al.
    Psychopharmacology (Berl)  2015;18:pyv045
  5. Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation.
    Authors: Jury Et al.
    PLoS One  2015;10:e0117339
  6. Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter.
    Authors: Nolan Et al.
    ACS Chem Neurosci  2014;5:784
  7. The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
    Authors: Jim&eacutenez-Sánchez Et al.
    Neuropsychopharmacology  2014;39:2673
  8. A translational rodent assay of affective biases in depression and antidepressant therapy.
    Authors: Stuart Et al.
    Neuropsychopharmacology  2013;38:1625
  9. Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
    Authors: Hutchinson Et al.
    Cardiovasc Res  2012;37:321
  10. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    PLoS One  2012;20:1516

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