Citalopram hydrobromide

  ( 12 citations )    
Product Datasheet
Catalog Number:1427
Chemical Name:1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Deuterated analog also available.

Technical Data
  • M.Wt:
    405.31
  • Formula:
    C20H21FN2O.HBr
  • Solubility:
    Soluble to 50 mM in ethanol and to 10 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    59729-32-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:

12 Citations: Showing 1 - 10
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  1. Psychopharmacological characterisation of the successive negative contrast effect in rats.
    Authors: Phelps Et al.
    Mol Ther  2015;232:2697
  2. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
    Authors: Munari Et al.
    Psychopharmacology (Berl)  2015;18:pyv045
  3. Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation.
    Authors: Jury Et al.
    PLoS One  2015;10:e0117339
  4. Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter.
    Authors: Nolan Et al.
    ACS Chem Neurosci  2014;5:784
  5. The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
    Authors: Jim&eacutenez-Sánchez Et al.
    Neuropsychopharmacology  2014;39:2673
  6. A translational rodent assay of affective biases in depression and antidepressant therapy.
    Authors: Stuart Et al.
    Neuropsychopharmacology  2013;38:1625
  7. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Cardiovasc Res  2012;37:321
  8. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    PLoS One  2012;20:1516
  9. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Int J Neuropsychopharmacol  2010;85:593
  10. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med  2010;16:694
  11. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry.
    Authors: Maciag Et al.
    Neuropsychopharmacology  2006;31:47
  12. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res  2006;1125:171
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