CK 666

Catalog # Availability Size / Price Qty
3950/10
3950/50
CK 666 | CAS No. 442633-00-3 | Actin-related Products
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Description: Arp2/3 inhibitor; inhibits actin polymerization

Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Purity: ≥99%

Product Details
Citations (14)
Reviews

Biological Activity

Inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).

Technical Data

M.Wt:
296.34
Formula:
C18H17FN2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
442633-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
    Nolen et al.
    Nature, 2009;460:1031
  2. X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors.
    Han and Nolen
    1751 ACSB 2009 Abstracts. American Society for Cel, 2009;

Product Datasheets

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Citations for CK 666

The citations listed below are publications that use Tocris products. Selected citations for CK 666 include:

14 Citations: Showing 1 - 10

  1. Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
    Authors: Roesler Et al.
    Front Cell Neurosci  2019;13:330
  2. Bimodal sensing of guidance cues in mechanically distinct microenvironments.
    Authors: Tabdanov Et al.
    Nat Commun  2018;9:4891
  3. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
    Authors: Yamagashi Et al.
    Biochem Biophys Res Commun  2018;496:834
  4. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
    Authors: Sepúlveda-Ramírez Et al.
    Dev Biol  2018;437:140
  5. c-Src activity is differentially required by cancer cell motility modes.
    Authors: Logue Et al.
    Oncogene  2018;37:2104
  6. Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.
    Authors: Tabdanov Et al.
    Cell Rep  2018;25:328
  7. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun  2017;8:14348
  8. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  9. Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
    Authors: Basu Et al.
    Eneuro  2016;3
  10. Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.
    Authors: Panousopoulou Et al.
    J Cell Sci  2016;129:1915

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