Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Biological ActivityInhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen et al.
X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors.
Han and Nolen
1751 ACSB 2009 Abstracts. American Society for Cel, 2009;
Citations for CK 666
The citations listed below are publications that use Tocris products. Selected citations for CK 666 include:
14 Citations: Showing 1 - 10
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
Authors: Roesler Et al.
Front Cell Neurosci 2019;13:330
Bimodal sensing of guidance cues in mechanically distinct microenvironments.
Authors: Tabdanov Et al.
Nat Commun 2018;9:4891
Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
Authors: Yamagashi Et al.
Biochem Biophys Res Commun 2018;496:834
Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
Authors: Sepúlveda-Ramírez Et al.
Dev Biol 2018;437:140
c-Src activity is differentially required by cancer cell motility modes.
Authors: Logue Et al.
Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.
Authors: Tabdanov Et al.
Cell Rep 2018;25:328
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Nat Commun 2017;8:14348
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
Authors: Basu Et al.
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.
Authors: Panousopoulou Et al.
J Cell Sci 2016;129:1915
Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
Authors: Sorce Et al.
Cell Calcium 2015;6:8872
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Authors: Tornavaca Et al.
Proc Natl Acad Sci U S A 2015;208:821
Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.
Authors: Moreau Et al.
Nat Commun 2015;112:12151
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
Authors: Dalton and Carroll
J Cell Sci 2013;126:2955
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