Catalog Number: 3950
Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Biological Activity
Inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
    Nolen et al.
    Nature, 2009;460:1031
  2. X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors.
    Han and Nolen
    1751 ACSB 2009 Abstracts. American Society for Cel, 2009;

The citations listed below are publications that use Tocris products. Selected citations for CK 666 include:

Showing Results 1 - 4 of 4

  1. Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
    Authors: Sorce Et al.
    Cell Calcium
  2. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
    Authors: Tornavaca Et al.
    Proc Natl Acad Sci U S A
  3. Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.
    Authors: Moreau Et al.
    Nat Commun
  4. Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
    Authors: Dalton and Carroll
    J Cell Sci
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