Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Biological ActivityCK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen et al.
X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors.
Han and Nolen
1751 ACSB 2009 Abstracts. American Society for Cel, 2009;
Citations for CK 666
The citations listed below are publications that use Tocris products. Selected citations for CK 666 include:
14 Citations: Showing 1 - 10
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
Authors: Roesler Et al.
Front Cell Neurosci 2019;13:330
Bimodal sensing of guidance cues in mechanically distinct microenvironments.
Authors: Tabdanov Et al.
Nat Commun 2018;9:4891
Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
Authors: Yamagashi Et al.
Biochem Biophys Res Commun 2018;496:834
Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
Authors: Sepúlveda-Ramírez Et al.
Dev Biol 2018;437:140
c-Src activity is differentially required by cancer cell motility modes.
Authors: Logue Et al.
Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.
Authors: Tabdanov Et al.
Cell Rep 2018;25:328
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Nat Commun 2017;8:14348
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
Authors: Basu Et al.
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.
Authors: Panousopoulou Et al.
J Cell Sci 2016;129:1915
Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
Authors: Sorce Et al.
Cell Calcium 2015;6:8872
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Authors: Tornavaca Et al.
Proc Natl Acad Sci U S A 2015;208:821
Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.
Authors: Moreau Et al.
Nat Commun 2015;112:12151
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
Authors: Dalton and Carroll
J Cell Sci 2013;126:2955
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