Catalog Number: 4984
Alternate Names: CK-0157869
Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
Biological Activity
Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.
Technical Data
  • M.Wt:
    394.28
  • Formula:
    C17H16BrNO3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    388592-44-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
    Nolen et al.
    Nature, 2009;460:1031
  2. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
    Hetrick et al.
    Chem Biol., 2013;20:701
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CK 869 include:

1 Citations: Showing 1 - 1

  1. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun 2017;8:14348

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