Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
Biological ActivityInhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen et al.
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
Hetrick et al.
Chem Biol., 2013;20:701
Citations for CK 869
The citations listed below are publications that use Tocris products. Selected citations for CK 869 include:
2 Citations: Showing 1 - 2
Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
Authors: Yamagashi Et al.
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Nat Commun 2017;8:14348
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