Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50
= 11 μ
M). Does not inhibit budding or fission yeast Arp2/3 complexes.
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All Tocris products are intended for laboratory research use only.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen et al.
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
Hetrick et al.
Chem Biol., 2013;20:701