Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
Biological ActivityInhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen et al.
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
Hetrick et al.
Chem Biol., 2013;20:701
Citations for CK 869
The citations listed below are publications that use Tocris products. Selected citations for CK 869 include:
2 Citations: Showing 1 - 2
Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
Authors: Yamagashi Et al.
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Nat Commun 2017;8:14348
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CK 869
There are currently no reviews for this product. Be the first to review CK 869 and earn rewards!
Have you used CK 869?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image