CL 075
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Description: TLR8 agonist
Chemical Name: 2-Propylthiazolo[4,5-c]quinolin-4-amine
Purity: ≥98%
Biological Activity
CL 075 is a TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat. No. 4287).Technical Data
M.Wt:
243.33
Formula:
C13H13N3S
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
256922-53-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
Pang Maoyin, Bala Shashi, Kodys Karen et al.
BMC Immunol -
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.
Gorden et al.
J.Immunol., 2005;174:1259 -
Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075.
Spranger et al.
J.Immunol., 2010;185:738
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