Poly(I:C)

Tocris Bioscience | Catalog # 4287

TLR3 agonist
Tocris Bioscience

Key Product Details

Description

TLR3 agonist
View all Toll-like Receptor Agonists »

Product Description

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis.

To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

Product Specifications for Poly(I:C)

Formula

(C10H13N4O8P)x.(C9H14N3O8P)x

Storage

Store at -20°C

Chemical Name

Polyinosinic-polycytidylic acid sodium salt

CAS Number

42424-50-0

PubChem ID

32744

InChI Key

ACEVNMQDUCOKHT-ZLOOHWKQSA-N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 3mg/ml in water

Calculators

Calculate the dilution required to prepare a stock solution.

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Product Documents for Poly(I:C)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Poly(I:C)

For research use only

Customer Reviews for Poly(I:C) (2)

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  • Poly IC
    Name: shubham dubey
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: 16HBE
    Verified Customer | Posted 12/22/2021
    To activate TLR3
    Poly(I:C) 4287
  • Good product
    Name: KANG LE
    Assay Type: In Vitro
    Cell Line/Tissue: THP1
    Verified Customer | Posted 04/24/2018
    I used this product to activate TLR3.

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