Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Biological ActivityPoly(I:C) is a synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075. Transfection into NIT-1 β cells induces β-cell apoptosis. Commonly used to stimulate immune system activation in vivo. Also promotes maturation of hPSC-derived cardiomyocytes.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
- To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.
Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075.
Spranger et al.
Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL).
Robbins et al.
Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12.
Rouas et al.
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
West et al.
Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation.
Biermann et al.
Stem Cells, 2019;37:910
Citations for Poly(I:C)
The citations listed below are publications that use Tocris products. Selected citations for Poly(I:C) include:
2 Citations: Showing 1 - 2
Microglial nodules provide the environment for pathogenic T cells in human encephalitis.
Authors: Tröscher Et al.
Acta Neuropathol 2019;137:619
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Authors: Yu Et al.
Mol Cell 2018;72:999
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I used this product to activate TLR3.