Poly(I:C)

Catalog # Availability Size / Price Qty
4287/10
4287/50
Poly(I:C) | CAS No. 42424-50-0 | Toll-like Receptor Agonists
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Description: TLR3 agonist

Chemical Name: Polyinosinic-polycytidylic acid sodium salt

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induce β-cell apoptosis. Commonly used to stimulate immune system activation in vivo.

To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

Technical Data

Formula:
(C10H13N4O8P)x.(C9H14N3O8P)x
Solubility:
Soluble to 3 mg/ml in water
Storage:
Store at -20°C
CAS No:
42424-50-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.

Product Datasheets

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Citations for Poly(I:C)

The citations listed below are publications that use Tocris products. Selected citations for Poly(I:C) include:

3 Citations: Showing 1 - 3

  1. Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks.
    Authors: Tachibana Et al.
    Comp.Biochem.Physiol.A Mol.Integr.Physiol.  2022;269:111211
  2. Microglial nodules provide the environment for pathogenic T cells in human encephalitis.
    Authors: Tröscher Et al.
    Acta Neuropathol  2019;137:619
  3. Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
    Authors: Yu Et al.
    Mol Cell  2018;72:999

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Reviews for Poly(I:C)

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Good product
By KANG LE on 04/24/2018

I used this product to activate TLR3.


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