Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Biological ActivityPoly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induce β-cell apoptosis. Commonly used to stimulate immune system activation in vivo.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
- To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.
Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075.
Spranger et al.
Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL).
Robbins et al.
Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12.
Rouas et al.
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
West et al.
Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation.
Biermann et al.
Stem Cells, 2019;37:910
Citations for Poly(I:C)
The citations listed below are publications that use Tocris products. Selected citations for Poly(I:C) include:
3 Citations: Showing 1 - 3
Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks.
Authors: Tachibana Et al.
Comp.Biochem.Physiol.A Mol.Integr.Physiol. 2022;269:111211
Microglial nodules provide the environment for pathogenic T cells in human encephalitis.
Authors: Tröscher Et al.
Acta Neuropathol 2019;137:619
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Authors: Yu Et al.
Mol Cell 2018;72:999
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I used this product to activate TLR3.