Catalog Number: 4287
Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Biological Activity
Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat.No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.
Technical Data
  • Formula:
    (C10H13N4O8P)x.(C9H14N3O8P)x
  • Solubility:
    Soluble to 3 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    24939-03-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • To prevent denaturation this product should be reconstituted in solutions with physiological salt concentrations.
Background References
  1. Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL).
    Robbins et al.
    Endocrinology, 2003;144:4616
  2. Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12.
    Rouas et al.
    Int.Immunol., 2004;16:767
  3. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
    West et al.
    Nature, 2011;472:476
  4. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075.
    Spranger et al.
    J.Immunol., 2010;185:738

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