Potent steroidal androgen receptor agonist (IC50
= 12 nM). Mimics the action of 5α
-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α
-reductase type I and II (IC50
values are 6 and 10 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro].
Tolman et al.
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Schmidt et al.