CL 82198 hydrochloride

Catalog # Availability Size / Price Qty
CL 82198 hydrochloride | CAS No. 1188890-36-9 | Synthetic Metalloprotease Inhibitors
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Description: Selective inhibitor of MMP-13

Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design.
    Chen et al.
    J.Am.Chem.Soc., 2000;122:9648
  2. IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75.
    Borg et al.
    Endocrine Abstr., 2003;5:122
  3. PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish.
    Lisse et al.
    Proc Natl Acad Sci U S A, 2016;113:E2189

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Citations for CL 82198 hydrochloride

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