Selective inhibitor of MMP-13 (89% inhibition at 10 μ
g/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro
invasion by the human pituitary adenoma cell line HP75.
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Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design.
Chen et al.
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