Selective KCC2 K+
cotransporter activator (EC50
= 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA
receptors, as well as 55 other receptors. Enhances Cl-
transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
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All Tocris products are intended for laboratory research use only.
Chloride extrusion enhancers as novel therapeutics for neurological diseases.
Gagnon et al.