CLP 257

Key Product Details

Product Description

CLP 257 is a selective KCC2 K⁺-Cl^- cotransporter activator (EC₅₀ = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABA_A receptors, as well as 55 other receptors. Enhances Cl^- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

Product Specifications for CLP 257

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CLP 257

The following data is based on the product molecular weight 307.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Gagnon Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 2013 PMID: 24097188

Product Documents for CLP 257