Chemical Name: 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Biological ActivityAldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC50 values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133+ ovarian cancer stem cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells.
Chefetz et al.
Cell Rep., 2019;26:3061
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
Morgan & Hurley
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