Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Biological ActivitySTING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Rat and human STINGs profile similarly towards anticancer/antiviral compounds.
Zhang et al.
Sci. Rep., 2015;5:18035
Targeting STING with covalent small-molecule inhibitors.
Haag et al.
Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar et al.
EMBO J., 2013;32:1440
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