CMA
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Description: Murine-selective STING agonist
Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Purity: ≥98%
Biological Activity
CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.Technical Data
M.Wt:
253.25
Formula:
C15H11NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
38609-97-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Rat and human STINGs profile similarly towards anticancer/antiviral compounds.
Zhang et al.
Sci. Rep., 2015;5:18035 -
Targeting STING with covalent small-molecule inhibitors.
Haag et al.
Nature, 2018;559:269 -
Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar et al.
EMBO J., 2013;32:1440
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