Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Biological ActivityColchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Analysis of the colchicine-binding site of β-tubulin.
FEBS Lett., 1992;297:205
Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch.
Bai et al.
Interactions of colch. with tubulin.
The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help?
Ribeiro et al.
The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation.
Martinez et al.
Citations for Colchicine
The citations listed below are publications that use Tocris products. Selected citations for Colchicine include:
5 Citations: Showing 1 - 5
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther 2017;16(6):1021
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
Genetic screening reveals a link between Wnt signaling and antitubulin drugs.
Authors: Khan Et al.
Pharmacogenomics J 2016;16:164
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Authors: Melemedjian Et al.
Mol Pain 2014;10:45
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