Catalog Number: 1364
Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Biological Activity
Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
Technical Data
  • M.Wt:
    399.44
  • Formula:
    C22H25NO6
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    64-86-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine.
    Bai et al.
    J.Biol.Chem., 1996;271:12639
  2. Analysis of the colchicine-binding site of β-tubulin.
    Burns
    FEBS Lett., 1992;297:205
  3. Interactions of colchicine with tubulin.
    Hastie
    Pharmacol.Ther., 1991;51:377
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Colchicine include:

1 Citations: Showing 1 - 1

  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021

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