Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Biological ActivityPlant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Analysis of the colchicine-binding site of β-tubulin.
FEBS Lett., 1992;297:205
Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch.
Bai et al.
Interactions of colch. with tubulin.
Citations for Colchicine
The citations listed below are publications that use Tocris products. Selected citations for Colchicine include:
5 Citations: Showing 1 - 5
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther 2017;16(6):1021
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
Genetic screening reveals a link between Wnt signaling and antitubulin drugs.
Authors: Khan Et al.
Pharmacogenomics J 2016;16:164
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Authors: Melemedjian Et al.
Mol Pain 2014;10:45
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Colchicine
Average Rating: 5 (Based on 1 Review)
Have you used Colchicine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.