Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
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Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine.
Bai et al.
Analysis of the colchicine-binding site of β-tubulin.
FEBS Lett., 1992;297:205
Interactions of colchicine with tubulin.