Catalog Number: 1495
Alternate Names: CRC 87-09, NSC 817373
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Biological Activity
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.
Technical Data
  • M.Wt:
    316.35
  • Formula:
    C18H20O5
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    117048-59-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor.
    Dorr et al.
    Invest.New Drugs, 1996;14:131
  2. Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
    Lin et al.
    J.Pharmacol.Exp.Ther., 2007;323:365
  3. Potent anti-metastatic activity of combretastatin-A4.
    Griggs et al.
    Int.J.Oncol., 2001;19:821
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Combretastatin A4 include:

1 Citations: Showing 1 - 1

  1. Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity.
    Authors: Arora Et al.
    J Biol Chem 2009;69:1910

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