Biological ActivityCompstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.
Control Peptide also available.
(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.
Sahu et al.
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
Fiane et al.
Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons.
Soulika et al.
Citations for Compstatin
The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:
6 Citations: Showing 1 - 6
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG.
Authors: Larsen Et al.
Front Immunol 2019;9:3088
The role of platelets in mediating a response to human influenza infection.
Authors: Koupenova Et al.
Nat Commun 2019;10:1780
Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes.
Authors: Lee Et al.
Cell Death Dis 2014;5:e1192
Inhibitors of C5 complement enhance vaccinia virus oncolysis.
Authors: Magge Et al.
Cancer Gene Ther 2013;20:342
Is asthma related to choroidal neovascularization?
Authors: Sun Et al.
Pharmacol Res Perspect 2012;7:e35415
Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the IF.-inducible immunoproteasome.
Authors: Yang Et al.
Arterioscler Thromb Vasc Biol 2009;29:1213
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Reviews for Compstatin
Average Rating: 4 (Based on 1 Review)
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We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.