Compstatin

  ( 4 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2585
Chemical Name:
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.

Control Peptide also available.

Technical Data
  • M.Wt:
    1550.77
  • Formula:
    C66H99N23O17S2
  • Sequence:
    ICVVQDWGHHRCT

    (Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    206645-99-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:

4 Citations: Showing 1 - 4
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  1. Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes.
    Authors: Lee Et al.
    Cell Death Dis  2014;5:e1192
  2. Inhibitors of C5 complement enhance vaccinia virus oncolysis.
    Authors: Magge Et al.
    Cancer Gene Ther  2013;20:342
  3. Is asthma related to choroidal neovascularization?
    Authors: Sun Et al.
    Pharmacol Res Perspect  2012;7:e35415
  4. Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome.
    Authors: Yang Et al.
    Arterioscler Thromb Vasc Biol  2009;29:1213

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Average Rating: 4 (Based on 1 review)

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  Very Good
  Mouse Ahsan Habib 01/06/2018
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Species Mouse

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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