Compstatin

Catalog # Availability Size / Price Qty
2585/1
Compstatin
1 Image
Description: C3-binding protein, inhibits complement activation
Product Details
Citations (6)
Supplemental Products
Reviews (1)

Biological Activity

Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.

Control Peptide also available.

Technical Data

M.Wt:
1550.77
Formula:
C66H99N23O17S2
Sequence:
ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
206645-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Compstatin

The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:

6 Citations: Showing 1 - 6

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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein
By Ahsan Habib on 01/06/2018
Species: Mouse

We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.


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