Compstatin

Tocris Bioscience | Catalog # 2585

C3-binding peptide; inhibits complement activation
Tocris Bioscience

Key Product Details

Description

C3-binding peptide; inhibits complement activation
View all Complement Signaling inhibitors »

Product Description

Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Control Peptide also available.

Product Specifications for Compstatin

Molecular Weight

1550.77

Formula

C66H99N23O17S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

206645-99-0

PubChem ID

25082538

InChI Key

RDTRHBCZFDCUPW-KWICJJCGSA-N

SMILES

[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 58 publications citing the usage of this product.

Product Documents for Compstatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Compstatin

For research use only

Customer Reviews for Compstatin (1)

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  • We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein
    Name: Ahsan Habib
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: CHO/APPwt
    Verified Customer | Posted 01/06/2018
    We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.

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