Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50
= 28 μ
M) and activation of classical and alternative complement pathways (IC50
values are 63 and 12 μ
M respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo
pig kidneys perfused with human blood and inhibits in vivo
heparin/protamine-induced complement activation in baboons. Control peptide
available (Cat. No. 3796).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.
Sahu et al.
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
Fiane et al.
Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons.
Soulika et al.
The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:
Showing Results 1 - 3 of 3