Catalog Number: 2585
Biological Activity
Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.

Control Peptide also available.

Technical Data
  • M.Wt:
    1550.77
  • Formula:
    C66H99N23O17S2
  • Sequence:
    ICVVQDWGHHRCT

    (Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    206645-99-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.
    Sahu et al.
    J.Immunol., 1996;157:884
  2. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
    Fiane et al.
    Xenotransplantation, 1999;6:52
  3. Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons.
    Soulika et al.
    Clin.Immunol., 2000;96:212
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Compstatin include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes.
    Authors: Lee Et al.
    Cell Death Dis 2014;5:e1192
  2. Inhibitors of C5 complement enhance vaccinia virus oncolysis.
    Authors: Magge Et al.
    Cancer Gene Ther 2013;20:342
  3. Is asthma related to choroidal neovascularization?
    Authors: Sun Et al.
    Pharmacol Res Perspect 2012;7:e35415
Tocris Peptides
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Compstatin control peptide

3796  
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