Conduritol B epoxide

Tocris Bioscience | Catalog # 7056

Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models
Tocris Bioscience

Key Product Details

Description

Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models
View all Glycosylase Inhibitors »

Product Description

Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (Ki = 53 μM; IC50 = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.

Product Specifications for Conduritol B epoxide

Molecular Weight

162.14

Formula

C6H10O5

Storage

Store at -20°C

Chemical Name

DL-1,2-Anhydro-myo-inositol

CAS Number

6090-95-5

PubChem ID

119054

InChI Key

XZVMSMRXIHXONQ-XINMYZFBSA-N

SMILES

O[C@H]1[C@H]2O[C@H]2[C@@H]([C@H]([C@@H]1O)O)O.O[C@@H]3[C@@H]4O[C@@H]4[C@H]([C@@H]([C@H]3O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.21 100
DMSO 16.21 100

Preparing Stock Solutions for Conduritol B epoxide

The following data is based on the product molecular weight 162.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.17 mL 30.84 mL 61.68 mL
5 mM 1.23 mL 6.17 mL 12.34 mL
10 mM 0.62 mL 3.08 mL 6.17 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Conduritol B epoxide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Conduritol B epoxide

For research use only

Citations for Conduritol B epoxide

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