Conduritol B epoxide
Chemical Name: DL-1,2-Anhydro-myo-Inositol
Biological ActivityConduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (Ki = 53 μM; IC50 = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Witte et al.
Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis.
Henriques et al.
Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish.
Artola et al.
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling.
Kuo et al.
FEBS J., 2019;286:584
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