Conduritol B epoxide

Catalog # Availability Size / Price Qty
Conduritol B epoxide | CAS No. 6090-95-5 | Glycosylase Inhibitors
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Description: Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models

Chemical Name: DL-1,2-Anhydro-myo-Inositol

Product Details

Biological Activity

Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (Ki = 53 μM; IC50 = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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