CORM 2
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Description: Carbon monoxide-releasing molecule
Chemical Name: Tricarbonyldichlororuthenium(II) dimer
Biological Activity
CORM 2 is a carbon monoxide-releasing molecule. Causes vasodilatation in isolated aortic rings in vitro. Cytotoxic to smooth muscle cells in vitro after prolonged (24h) exposure. Exhibits antihypertensive effects in vivo. Reduces tight-junction disruption in intestinal mucosa in a rat sepsis model.Technical Data
M.Wt:
512.01
Formula:
C6Cl4O6Ru2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
22594-69-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Carbon monoxide-releasing molecule-2 reduces intestinal epithelial tight-junction damage and mortality in septic rats.
Zhang et al.
PLoS One, 2015;10:e0145988 -
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities.
Motterlini et al.
Circ.Res., 2002;90:E17
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