Biological ActivityEndogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo. Also potent MRGPRX2 agonist.
(Modifications: Disulfide bridge between 2 - 13)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland.
Deghenghi et al.
Identification and characterization of a novel human cortisan-like peptide.
Fukusumi et al.
Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.
Spier and de Lecea
Brain Res., 2000;33:228
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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VersaClone cDNA Plasmids
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