Catalog Number: 3374
Biological Activity
Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
Technical Data
  • M.Wt:
    1721.03
  • Formula:
    C81H113N19O19S2
  • Sequence:
    PCKNFFWKTFSSCK

    (Modifications: Disulfide bridge between 2 - 13)

  • Solubility:
    Soluble to 0.70 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    193829-96-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland.
    Deghenghi et al.
    J.Endocrinol.Invest., 2001;24:RC1
  2. Identification and characterization of a novel human cortisan-like peptide.
    Fukusumi et al.
    Biochem.Biophys.Res.Comm., 1997;232:157

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