Cortistatin 14

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Cortistatin 14
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Description: Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Purity: ≥95%

Product Details
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Biological Activity

Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo. Also potent MRGPRX2 agonist.

Technical Data


(Modifications: Disulfide bridge: 2-13)

Soluble to 0.70 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland.
    Deghenghi et al.
    J.Endocrinol.Invest., 2001;24:RC1
  2. Identification and characterization of a novel human cortisan-like peptide.
    Fukusumi et al.
    Biochem.Biophys.Res.Comm., 1997;232:157
  3. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.
    Spier and de Lecea
    Brain Res., 2000;33:228
  4. Pharmacology and signaling of MAS-related G protein-coupled receptors.
    Solinski et al.
    Pharmacol.Rev., 2014;66:570

Product Datasheets

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