Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1
) and prevents somatostatin-14 binding (IC50
values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1
receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo
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Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland.
Deghenghi et al.
Identification and characterization of a novel human cortisan-like peptide.
Fukusumi et al.