Biological ActivityCortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
(Modifications: Disulfide bridge: 2-13)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland.
Deghenghi et al.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for Cortistatin 14
There are currently no reviews for this product. Be the first to review Cortistatin 14 and earn rewards!
Have you used Cortistatin 14?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image