Biological ActivityCortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo. Also potent MRGPRX2 agonist.
(Modifications: Disulfide bridge between 2 - 13)
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Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland.
Deghenghi et al.
Identification and characterization of a novel human cortisan-like peptide.
Fukusumi et al.
Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.
Spier and de Lecea
Brain Res., 2000;33:228
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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VersaClone cDNA Plasmids
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