Costunolide
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Purity: ≥97%
Biological Activity
Costunolide is an inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors
N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal
PLoS ONE, 2017;12(6):e0179202. -
Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi.
Park et al.
J.Nat.Prod., 1996;59:1128 -
Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.
Jeong et al.
Cancer Lett., 2002;187:129 -
Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells.
Choi et al.
Cancer Lett., 2005;227:153
Product Datasheets
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Citations for Costunolide
The citations listed below are publications that use Tocris products. Selected citations for Costunolide include:
5 Citations: Showing 1 - 5
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Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity.
Authors: Liu Et al.
Nat Commun 2018;9:4657
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Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.
Authors: Ahmad Et al.
J Neurochem 2017;143:671
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Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.
Authors: Ahmad Et al.
Cell Death Dis 2016;7:e2213
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Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium).
Authors: Ramirez Et al.
PLoS One 2013;8:e65030
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Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
Authors: Liu Et al.
Neuron 2011;6:e23255
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