Costunolide

Key Product Details

Product Description

Costunolide is an inhibitor of human telomerase activity (IC₅₀ = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

Product Specifications for Costunolide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Costunolide

The following data is based on the product molecular weight 232.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.61 mL	43.04 mL	86.09 mL
2.5 mM	1.72 mL	8.61 mL	17.22 mL
5 mM	0.86 mL	4.30 mL	8.61 mL
25 mM	0.17 mL	0.86 mL	1.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Jeong Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 2002 PMID: 12359360
• Choi Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 2005 PMID: 16112418
• Park Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 1996 PMID: 8988596

Product Documents for Costunolide