Costunolide

  ( 3 citations )    
Product Datasheet
Catalog Number:2483
Chemical Name:(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Product Details
Citations (3)
Reviews
Biological Activity
Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
Technical Data
  • M.Wt:
    232.32
  • Formula:
    C15H20O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    553-21-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Costunolide include:

3 Citations: Showing 1 - 3
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  1. Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.
    Authors: Ahmad Et al.
    Cell Death Dis  2016;7:e2213
  2. Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium).
    Authors: Ramirez Et al.
    PLoS One  2013;8:e65030
  3. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
    Authors: Liu Et al.
    Neuron  2011;6:e23255

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