Costunolide

Catalog # Availability Size / Price Qty
2483/10
2483/1
Costunolide | CAS No. 553-21-9 | Telomerase Inhibitors
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Description: Inhibitor of human telomerase activity

Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one

Purity: ≥97%

Product Details
Citations (5)
Reviews

Biological Activity

Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

Technical Data

M.Wt:
232.32
Formula:
C15H20O2
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
553-21-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Costunolide

The citations listed below are publications that use Tocris products. Selected citations for Costunolide include:

5 Citations: Showing 1 - 5

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