Catalog Number: 2483
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Biological Activity
Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.
    Jeong et al.
    Cancer Lett., 2002;187:129
  2. Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi.
    Park et al.
    J.Nat.Prod., 1996;59:1128
  3. Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells.
    Choi et al.
    Cancer Lett., 2005;227:153

The citations listed below are publications that use Tocris products. Selected citations for Costunolide include:

Showing Results 1 - 2 of 2

  1. Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium).
    Authors: Ramirez Et al.
    PLoS One
  2. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
    Authors: Liu Et al.
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