CP 122721 hydrochloride

Tocris Bioscience | Catalog # 3649

High affinity NK1 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity NK1 antagonist
View all NK1 Receptor Antagonists »

Product Description

CP 122721 hydrochloride is a high affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

Product Specifications for CP 122721 hydrochloride

Molecular Weight

453.33

Formula

C20H23F3N2O2.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride

CAS Number

145877-52-7

PubChem ID

90664465

InChI Key

AVTRGAPFNJEOTQ-FFUVTKDNSA-N

SMILES

Cl.Cl.COC1=C(CN[C@H]2CCCN[C@H]2C2=CC=CC=C2)C=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.33 100
DMSO 45.33 100

Preparing Stock Solutions for CP 122721 hydrochloride

The following data is based on the product molecular weight 453.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.06 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.10 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CP 122721 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CP 122721 hydrochloride

For research use only

Citations for CP 122721 hydrochloride

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