CP 122721 hydrochloride

Catalog # Availability Size / Price Qty
3649/25
3649/5
Cat.No. 3649 - CP 122721 hydrochloride | C20H23F3N2O2.2HCl | CAS No. 145877-52-7
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Description: High affinity NK1 antagonist

Chemical Name: (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride

Purity: ≥98%

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Biological Activity

High affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

Technical Data

M.Wt:
453.33
Formula:
C20H23F3N2O2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
145877-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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