CP 122721 hydrochloride
Chemical Name: (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride
Biological ActivityHigh affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets.
Gonsalves et al.
Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats.
Auais et al.
Am.J.Physiol. Lung Cell Mol.Physiol., 2003;285:L105
Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.
McLean et al.
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