CP 690550 citrate

Tocris Bioscience | Catalog # 4556

Potent JAK inhibitor
Tocris Bioscience

Key Product Details

Description

Potent JAK inhibitor

Alternative Names

Tofacitinib citrate
View all JAK Kinase Inhibitors »

Product Description

CP 690550 citrate is a potent JAK inhibitor (IC50 values are 1, 20, and 112 nM for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 690550 (Tofacitinib) is reviewed on the chemical probes website.

Product Specifications for CP 690550 citrate

Molecular Weight

504.49

Formula

C16H20N6O.C6H8O7

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate

CAS Number

540737-29-9

PubChem ID

10174505

InChI Key

SYIKUFDOYJFGBQ-YLAFAASESA-N

SMILES

C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.45 100

Preparing Stock Solutions for CP 690550 citrate

The following data is based on the product molecular weight 504.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.40 mL 1.98 mL 3.96 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Product Documents for CP 690550 citrate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CP 690550 citrate

For research use only

Citations for CP 690550 citrate

Customer Reviews for CP 690550 citrate (1)

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  • Worked for cytokine Elisa analysis
    Name: Scott Scarneo
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: RA FLS
    Verified Customer | Posted 02/06/2019
    Used for RA FLS Cytokine production of IL-6.
    CP 690550 citrate 4556

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