Catalog Number: 5973
Chemical Name: 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
Biological Activity
Potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.
    Jani et al.
    Cancer Res., 2007;67:9887
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