Catalog Number: 4190
Chemical Name: 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid
Biological Activity
Selective, high affinity PPARα agonist (Ki values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.
Technical Data
  • M.Wt:
    423.54
  • Formula:
    C26H33NO4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    702680-17-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo.
    Kane et al.
    Mol.Pharmacol., 2009;75:296
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 775146 include:

1 Citations: Showing 1 - 1

  1. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
    Authors: Nagiec Et al.
    Hum Mol Genet 2015;10:e0120295

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